Abstract
Background: Ferrocene is a potential pharmacophore for drug design and drug discovery.
Methods: Based on our previous good achievements (Med. Chem. commun., 2014,7,968-972), nineteen novel structures of 1,1’-ferrocene diformates bearing isoxazole moiety (3a-3s) were firstly synthesized in the current work and characterized by 1H NMR, 13C NMR, ESI-MS. Then, their cytotoxicity to A549, HCT116 and MCF-7 cell lines was evaluated using the MTT method.
Results: The results showed that most compounds exhibited higher potent cytotoxicity to A549, HCT116 and MCF-7 cell lines.
Conclusion: Especially, 3b, 3h, 3k, 3l, 3m, 3n, 3o, 3p and 3s simultaneously exhibited stronger inhibitory activity towards A549, HCT116 and MCF-7 cell lines than that of the reference drug cisplatin, which can be regarded as very promising metal-based lead compounds for anticancer agents.
Keywords: 1, 1`-ferrocene diformates, isoxazole moiety, synthesis, structural characterization, antitumor activity, cell lines.
Letters in Drug Design & Discovery
Title:Synthesis of 1,1’-Ferrocene Diformates Bearing Isoxazole Moiety and Preliminarily Cytotoxicity to A549, HCT116 and MCF-7 Cell Lines
Volume: 15 Issue: 11
Author(s): Jianping Yong*, Mingxue Yang, Canzhong Lu*Xiaoyuan Wu
Affiliation:
- Xiamen Institute of Rare-earth Materials, Chinese Academy of Sciences, Xiamen 361021,China
- Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002,China
Keywords: 1, 1`-ferrocene diformates, isoxazole moiety, synthesis, structural characterization, antitumor activity, cell lines.
Abstract: Background: Ferrocene is a potential pharmacophore for drug design and drug discovery.
Methods: Based on our previous good achievements (Med. Chem. commun., 2014,7,968-972), nineteen novel structures of 1,1’-ferrocene diformates bearing isoxazole moiety (3a-3s) were firstly synthesized in the current work and characterized by 1H NMR, 13C NMR, ESI-MS. Then, their cytotoxicity to A549, HCT116 and MCF-7 cell lines was evaluated using the MTT method.
Results: The results showed that most compounds exhibited higher potent cytotoxicity to A549, HCT116 and MCF-7 cell lines.
Conclusion: Especially, 3b, 3h, 3k, 3l, 3m, 3n, 3o, 3p and 3s simultaneously exhibited stronger inhibitory activity towards A549, HCT116 and MCF-7 cell lines than that of the reference drug cisplatin, which can be regarded as very promising metal-based lead compounds for anticancer agents.
Export Options
About this article
Cite this article as:
Yong Jianping*, Yang Mingxue , Lu Canzhong *, Wu Xiaoyuan , Synthesis of 1,1’-Ferrocene Diformates Bearing Isoxazole Moiety and Preliminarily Cytotoxicity to A549, HCT116 and MCF-7 Cell Lines, Letters in Drug Design & Discovery 2018; 15 (11) . https://dx.doi.org/10.2174/1570180815666180306124920
DOI https://dx.doi.org/10.2174/1570180815666180306124920 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Novel Hydroxamate and Anilide Derivatives as Potent Histone Deacetylase Inhibitors: Synthesis and Antiproliferative Evaluation
Current Medicinal Chemistry Prevention of Oxidative Stress and Diseases by Antioxidant Supplementation
Medicinal Chemistry Synthesis and Evaluation of N-Substituted Thiazolidine-2,4-dione Containing Pyrazole as a Potent Antimicrobial Agents
Anti-Infective Agents subject Index To Volume 2
Mini-Reviews in Medicinal Chemistry Synthesis of Novel Laurenditerpenol Analogues and their Evaluation as HIF-1 Activation Inhibitors
Letters in Organic Chemistry Withdrawal Notice: Fatal Outcomes from COVID-19 in Diabetes Patients and its Management: Impact of Diabetes and Other Comorbidities in COVID-19
Current Diabetes Reviews Free Radicals in Living Systems: In Vivo Detection of Bioradicals with EPR Spectroscopy
Current Organic Chemistry Determining Partition Coefficient (Log P), Distribution Coefficient (Log D) and Ionization Constant (pKa) in Early Drug Discovery
Combinatorial Chemistry & High Throughput Screening Epigenetic Modulators as Treatment Alternative to Diverse Types of Cancer
Current Medicinal Chemistry Latest Advances Towards the Discovery of 5-HT7 Receptor Ligands
Mini-Reviews in Medicinal Chemistry Computational Approaches for Fragment-Based and De Novo Design
Current Topics in Medicinal Chemistry Place of Nanofiltration for Assuring Viral Safety of Biologicals
Current Nanoscience An Update on Overcoming MDR1-Mediated Multidrug Resistance in Cancer Chemotherapy
Current Pharmaceutical Design Overview of Advancement in Biosensing Technology, Including its Applications in Healthcare
Current Pharmaceutical Biotechnology Lead Molecule Prediction and Characterization for Designing MERS-CoV 3C-like Protease Inhibitors: An In silico Approach
Current Computer-Aided Drug Design Viral Envelope Membrane: A Special Entry Pathway and a Promising Drug Target
Current Medicinal Chemistry COVID-19 and Diabetes Mellitus: Mutual Interplay of Two Diseases
Current Diabetes Reviews Design, Synthesis, and Activity Evaluation of a New 5-fluorouracil Prodrug Containing an Asn-Gly-Arg(NO2)COOCH3 Tripeptide
Protein & Peptide Letters Sex Steroids in Autoimmune Diseases
Current Topics in Medicinal Chemistry Patent Selections
Recent Advances in Computer Science and Communications