Background: Alzheimer’s disease (AD) is recognized as progressive multifaceted and multi-factorial
neurodegenerative disorder which causes dementia among elderly people. Although, researchers in this field have put
considerable efforts for the investigation of novel and appropriate therapeutic measures towards the cure of AD,
unfortunately, no effective prevention therapy for this disease is available till date. In fact, various aspects involved
in the onset and progression of AD are still disputed or uncovered. However, to achieve definite and direct cure of
AD, researcher’s attention has been drawn towards exploration of new therapeutics targets. In this review, we have
discussed the current progress of various aspects of pathophysiological mechanisms behind AD, together with recent
investigational therapeutic approaches and present tools with an emphasis on Multi Target Directed Drugs approach.
Method: We have scrutinized numerous peer-reviewed research articles to assemble and discuss significant research
findings and success achieved in the last decade pertinent to the application of Multi-Target Directed Drugs in the
treatment of AD.
Results: The main emphasis of the review was to understand the various aspects of pathophysiological mechanisms
involved in AD, along with the recent developments on potential AD targets and application of Multi-Target Directed
Drugs approach against AD. In addition, a brief overview of major drawbacks of conventional anti-AD drugs
has also been included. We found that several strategies including in silico approach could be used for multi-target
drug designing against AD. However, various synthetic/natural compounds and nano-formulations have the ability to
be developed as multi-target drugs for AD.
Conclusion: The present review comprises imperative information regarding AD pathology and disease process
along with recent researches going on to develop treatment strategies against AD. Thus, this review might be helpful
for physician, neurologist and scientist in understanding the diverse roots of AD for designing primary cure skills and
scaffold of pharmacological treatment to manage AD.