Background: Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN),
also known as Lyell's syndrome, are rare and life-threatening conditions, for which etiopathogenesis,
as well as pharmacotherapy, is yet unclear.
Case Report: A 45-year-old male patient by chance on re-exposure to Ofloxacin developed Severe
Cutaneous Adverse Drug Reaction (SCADR), diagnosed with toxic epidermal necrolysis. His
comorbid conditions and systemic complications of TEN lead him to death. In developing countries,
where antibiotics especially fluoroquinolones are widely prescribed, a physician should be now
vigilant for such kind of SCADRs because of increasing numbers of such kind of reports.