Space travelling has emerged as a hot issue in the world for various purposes. The man has
been trying to establish space stations and these efforts have turned into a reality. Longtime stay in
space is very much challenging due to various limiting environmental problems and health issues.
Among many, one is microgravity that generates uneven flow of fluids in the body which results in
oxidative stress. This stress markedly interrupts cerebral activity of astronauts both structurally and
functionally. This oxidative stress produced by microgravity distort many essential protein signaling
pathways that intricate various homeostatic behaviors within the body. The current knowledge of microgravity
effects on human brain especially the hypothalamus is expanding; whereas the comprehension
of the basic components of this phenomenon is restricted. Various literature reports already outlined
many key phenomena distorted by earth-based simulated microgravity. Therefore, an effort is being
made to summarize this bulk of knowledge in a simple way for the convenience of space research
community. This review will elucidate the effect of microgravity on the expression of key proteins involved
in structural, morphological, functional and molecular functions.
Keywords: Homeostasis, oxidative stress, reactive oxygen species, simulated microgravity, hypothalamus, differential expression.
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