Abstract
Background: The problem of bacterial resistance of Mycobacterium tuberculosis should be solved by seeking for alternative substances that potentially inhibit the growth or kill the bacteria. Ganoderma lucidum is one type of fungus which is potential to be an antimicrobial agent. This study aimed to determine the potential of G. lucidum on inhibiting the growth of multidrug-resistant bacteria of M. tuberculosis in vitro.
Methods: This study used a solid dilution method to test the extract of G. lucidum as an antibacterial agent.
Results and Conclusion: Results showed that all strains of multidrug-resistant tuberculosis (MDR-Tb) gave similar responses to G. lucidum extract at various concentrations. The bacteria did not grow on the medium containing G. lucidum extract at the smallest concentration of 12.5%, as well as concentrations of 25% and 50%. Ganoderma lucidum can be used as one of the alternatives for MDR-Tb drugs in the future.
Keywords: Antibacterial agent, Ganoderma lucidum, Mycobacterium tuberculosis, resistance, MDR-Tb, antimicrobialagents.
Anti-Infective Agents
Title:The Potential of Ganoderma Lucidum as Antimicrobial Agent for Multidrug- Resistant Mycobacterium Tuberculosis
Volume: 16 Issue: 1
Author(s): Meira Erawati*, Megah Andriany and Niken Safitri Dyan Kusumaningrum
Affiliation:
- Faculty of Medicine, Diponegoro University, Semarang,Indonesia
Keywords: Antibacterial agent, Ganoderma lucidum, Mycobacterium tuberculosis, resistance, MDR-Tb, antimicrobialagents.
Abstract: Background: The problem of bacterial resistance of Mycobacterium tuberculosis should be solved by seeking for alternative substances that potentially inhibit the growth or kill the bacteria. Ganoderma lucidum is one type of fungus which is potential to be an antimicrobial agent. This study aimed to determine the potential of G. lucidum on inhibiting the growth of multidrug-resistant bacteria of M. tuberculosis in vitro.
Methods: This study used a solid dilution method to test the extract of G. lucidum as an antibacterial agent.
Results and Conclusion: Results showed that all strains of multidrug-resistant tuberculosis (MDR-Tb) gave similar responses to G. lucidum extract at various concentrations. The bacteria did not grow on the medium containing G. lucidum extract at the smallest concentration of 12.5%, as well as concentrations of 25% and 50%. Ganoderma lucidum can be used as one of the alternatives for MDR-Tb drugs in the future.
Export Options
About this article
Cite this article as:
Erawati Meira *, Andriany Megah and Kusumaningrum Safitri Dyan Niken , The Potential of Ganoderma Lucidum as Antimicrobial Agent for Multidrug- Resistant Mycobacterium Tuberculosis, Anti-Infective Agents 2018; 16 (1) . https://dx.doi.org/10.2174/2211352516666180227135043
DOI https://dx.doi.org/10.2174/2211352516666180227135043 |
Print ISSN 2211-3525 |
Publisher Name Bentham Science Publisher |
Online ISSN 2211-3533 |
Call for Papers in Thematic Issues
An Overview of Drugs for Multiple Targets and Variants of SARS-CoV-2 Through Artificial Intelligence, Machine Learning, Deep Learning, and Experimental Analysis
The emergence and rapid evolution of SARS-CoV-2 variants have posed significant challenges in the ongoing fight against the COVID-19 pandemic. The development of effective treatments for multiple viral targets and variants demands innovative approaches, including artificial intelligence (AI), machine learning (ML), and deep learning (DL) techniques. This special issue aims ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Applications of Barbier Type Reactions in Carbohydrate Chemistry
Current Organic Synthesis EDITORIAL
Current Drug Therapy Itraconazole Induced Congestive Heart Failure, A Case Study
Current Drug Safety Development and Implementation of the DHAPP Military eHealth Information Network System
Current HIV Research Weight Loss in Older Persons: New Therapeutic Approaches
Current Pharmaceutical Design Recent Development of Coumarin Derivatives as Potential Antiplasmodial and Antimalarial Agents
Current Topics in Medicinal Chemistry Design, Synthesis and Anti-tuberculosis Activity of Hydrazones and N-acylhydrazones Containing Vitamin B6 and Different Heteroaromatic Nucleus
Letters in Drug Design & Discovery Association of Folate Level in Blood with the Risk of Schizophrenia
Combinatorial Chemistry & High Throughput Screening Hybridization Approach to Drug Discovery Inhibiting <i>Mycobacterium tuberculosis</i>-An Overview
Current Topics in Medicinal Chemistry Resistant Tuberculosis: the Latest Advancements of Second-line Antibiotic Inhalation Products
Current Pharmaceutical Design A Review on Genus Alseodaphne: Phytochemistry and Pharmacology
Mini-Reviews in Organic Chemistry Understanding Respiratory Syncytial Virus Infection to Improve Treatment and Immunity
Current Molecular Medicine Novel 2-Nitroimidazole and Imidazooxazole Derivatives and their Activity against <i>Trypanosoma cruzi</i> and <i>Mycobacterium tuberculosis</i>
Medicinal Chemistry Multiple Myeloma or Brucellosis: A Case Report
Infectious Disorders - Drug Targets Aspartic Peptidases of Human Pathogenic Trypanosomatids: Perspectives and Trends for Chemotherapy
Current Medicinal Chemistry QSAR Models for Anti-Malarial Activity of 4-Aminoquinolines
Current Computer-Aided Drug Design Circumscribing the Conformational Peptide Epitope Landscape
Current Pharmaceutical Design Vitamin D Deficiency May Be Associated with a More Rapid Decline in CD4 Cell Count to <350 Cells/µL in Untreated HIV-Infected Adults
Current HIV Research Synthesis and Biological Evaluation of N-(Alkyl)-2-Thiophen-2-Ylacetamides Series As A New Class of Antitubercular Agents
Letters in Drug Design & Discovery Gold - Old Drug with New Potentials
Current Medicinal Chemistry