The Potential of Ganoderma Lucidum as Antimicrobial Agent for Multidrug- Resistant Mycobacterium Tuberculosis

Author(s): Meira Erawati*, Megah Andriany, Niken Safitri Dyan Kusumaningrum.

Journal Name: Anti-Infective Agents
Anti-Infective Agents in Medicinal Chemistry

Volume 16 , Issue 1 , 2018

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Abstract:

Background: The problem of bacterial resistance of Mycobacterium tuberculosis should be solved by seeking for alternative substances that potentially inhibit the growth or kill the bacteria. Ganoderma lucidum is one type of fungus which is potential to be an antimicrobial agent. This study aimed to determine the potential of G. lucidum on inhibiting the growth of multidrug-resistant bacteria of M. tuberculosis in vitro.

Methods: This study used a solid dilution method to test the extract of G. lucidum as an antibacterial agent.

Results and Conclusion: Results showed that all strains of multidrug-resistant tuberculosis (MDR-Tb) gave similar responses to G. lucidum extract at various concentrations. The bacteria did not grow on the medium containing G. lucidum extract at the smallest concentration of 12.5%, as well as concentrations of 25% and 50%. Ganoderma lucidum can be used as one of the alternatives for MDR-Tb drugs in the future.

Keywords: Antibacterial agent, Ganoderma lucidum, Mycobacterium tuberculosis, resistance, MDR-Tb, antimicrobialagents.

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Article Details

VOLUME: 16
ISSUE: 1
Year: 2018
Page: [11 - 14]
Pages: 4
DOI: 10.2174/2211352516666180227135043

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