Background: The problem of bacterial resistance of Mycobacterium tuberculosis should be solved
by seeking for alternative substances that potentially inhibit the growth or kill the bacteria. Ganoderma lucidum
is one type of fungus which is potential to be an antimicrobial agent. This study aimed to determine the potential
of G. lucidum on inhibiting the growth of multidrug-resistant bacteria of M. tuberculosis in vitro.
Methods: This study used a solid dilution method to test the extract of G. lucidum as an antibacterial agent.
Results and Conclusion: Results showed that all strains of multidrug-resistant tuberculosis (MDR-Tb) gave
similar responses to G. lucidum extract at various concentrations. The bacteria did not grow on the medium
containing G. lucidum extract at the smallest concentration of 12.5%, as well as concentrations of 25% and
50%. Ganoderma lucidum can be used as one of the alternatives for MDR-Tb drugs in the future.
Keywords: Antibacterial agent, Ganoderma lucidum, Mycobacterium tuberculosis, resistance, MDR-Tb, antimicrobialagents.
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