Background: Mesenchymal Stem Cells (MSCs) are self-renewing, multipotent progenitor
cells with multilineage potential to differentiate into all cell types of mesodermal origin, such as adipocytes,
osteocytes and chondrocytes. Mesenchymal Stem Cells (MSCs) are adult stem cells which can be
isolated from human and animal sources.
Objective: Besides the differentiation potential of MSCs, these also regulate the immune response in
numerous ailments. The present review expedites the immunomodulating prospective of MSCs.
Methods: Scrupulous search of the literature and patents available on MSCs and their role in the immunomodulation
was carried out using Medline, PubMed, PubMed Central, Science Direct and other scientific
databases. The retrieved information has been analyzed and compiled.
Results: MSCs have unique regulation of microenvironment in the host tissue by secreting cytokines
and immune-receptors which results in immunomodulatory effects. MSCs can be used as an effective
tool in the treatment of chronic diseases because of its property to secrete anti-inflammatory molecules,
having multilineage potential and immunomodulation.
Conclusion: The present review is focused on the use of MSCs due to their unique immunomodulatory
characteristics. MSCs reach to the site of inflammation and interact with immune cells to bring immunosuppressive
and anti-inflammatory effects. Along with these unique therapeutic properties, MSCs
may be a useful therapeutic approach for various disorders.