Title:Protein Tyrosine Phosphatase as Potential Therapeutic Target in various Disorders
VOLUME: 11 ISSUE: 3
Author(s):Shivani Verma and Saurabh Sharma*
Affiliation:Department of Pharmacology, Indo-Soviet Friendship Pharmacy College (ISFCP), Moga, Punjab, Department of Pharmacology, School of Pharmaceutical and Allied Medical Sciences, CT University, Ferozepur Road, Ludhiana, Punjab
Keywords:Protein tyrosine phosphatase, cardiovascular diseases, metabolic disorders, neurodegenerative disease, therapeutic target,
pathological states.
Abstract:Background: Tyrosine-protein phosphatase is an enzyme that functions in a unit with
tyrosine kinases to regulate signaling pathways. Several members of the PTP family link to human
disease predisposition such as PTP1B, SH2, DEP1, and inhibition of these enzymes may represent
an effective palliative therapy.
Objective: This review aims to summarize the rapidly developing role of the PTPs in various
physiological and pathological states.
Results: Pharmacological inhibition of protein tyrosine phosphatase has been found to reduce endothelial
dysfunction in different cardiovascular diseases related to metabolic disorders and it can be
helpful for the management of other brain disorders associated with perhaps even in normal, agerelated
cognitive decline. Tyrosine-protein phosphates have both stimulatory and inhibitory consequences
on cancer-associated signaling pathways and deregulation of PTKs involves tumorgenesis.
Conclusion: Inhibition of protein tyrosine phosphatase plays an important function in the improvement
of various diseases such as metabolic, cardiovascular disorders, cancer and autoimmune
disease.
