Cytochrome P450s are enzymes capable of metabolizing a wide variety of drugs.
Their significant impact in drug discovery has led to extensive research, computationally and
experimentally, in order to explore how a chemical entity responds to metabolizing enzymes.
We present an overview of ligand-based and structure-based methodologies, along with pertinent
information on the structures, biology, and relevance of these enzymes.
Keywords: Cytochrome P450, drug metabolism, docking, 3D-QSAR, molecular dynamics, crystal structures, sites
Rights & PermissionsPrintExport