Introduction: Anvillea radiata Coss. & Durieu (Asteraceae) is an endemic plant from
North Africa (Morocco and Algeria). This plant has many traditional uses including treatment of
obesity and diabetes.
Aim of the Study: The study aims to evaluate the antidiabetic effect of aqueous extract of Anvillea
radiata (A. radiata) leaves on both normal and streptozotocin (STZ)-induced diabetic rats treated at
a dose of 10 mg/kg body weight for fifteen days. In addition, a preliminary pytochemical screening
for various components was realized.
Results: The blood glucose levels were lowered in diabetic rats treated with A. radiata, but no effect
was observed in normal rats. Single oral administration of A. radiata reduced blood glucose
levels from 22.15±0.98 mmol/L to 14.00±1.89 mmol/L (p<0.0001) six hours after administration in
STZ diabetic rats. Furthermore, blood glucose levels were decreased from 22.15±0.98 mmol/L to
4.39±1.29 mmol/L (p< 0.0001) in STZ diabetic rats after fifteen days of treatment. According to the
oral glucose tolerance test, the A. radiata (10 mg/kg) was shown to significantly prevent the increase
in blood glucose levels in normal treated rats 30 min, 60 min and 120 min after glucose administration
when compared to the control group. Concerning the preliminary phytochemical
screening of A. radiata, several compounds of chemicals have been found such as polyphenols,
flavonoids, tannins, mucilage, sesquiterpenes, terpenoids and carbohydrates.
Conclusion: The results show that aqueous extract of A. radiata leaves possesses a significant antihyperglycemic