The blood-brain barrier (BBB) is a layer between the blood circulation and neural tissue.
It plays a pivotal role in maintaining the vulnerable extracellular microenvironment in the neuronal
parenchyma. Neuroinflammatory events can result in BBB dysregulation by disturbing adherens
junctions (AJs) and tight junctions (TJs). VE-cadherin, as one of the most important components of
the vascular system, is specifically responsible for the assembly of AJs and BBB architecture. Here,
we present a review, which highlights recently available insights into the relationship between
the neuroinflammation and BBB dysregulation. We then explore the specific interaction between
VE-cadherin and BBB. Finally, we discuss the changes of VE-cadherin with different neurological
diseases from both experimental and clinical studies. An understanding of VE-cadherin in BBB
regulation may indicate that VE-cadherin can partially be a biomarker of neuroinflammation disease
and lead to novel approaches for abating BBB dysregulation under pathological conditions and the
opening of the BBB following central nervous system (CNS) drug delivery.
Keywords: Blood-brain barrier, endothelial cells, VE-cadherin, neuroinflammation, central nervous system, adherens junctions.
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