Updates on Genome-Wide Association Findings in Eating Disorders and Future Application to Precision Medicine

Author(s): Lauren Breithaupt , Christopher Hubel , Cynthia M. Bulik* .

Journal Name: Current Neuropharmacology

Volume 16 , Issue 8 , 2018

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Abstract:

Heterogeneity, frequent diagnostic fluctuation across presentations, and global concerns with the absence of effective treatments all encourage science that moves the field toward individualized or precision medicine in eating disorders. We review recent advances in psychiatric genetics focusing on genome-wide association studies (GWAS) in eating disorders. Given that the only eating disorder to be the subject of GWAS to date is anorexia nervosa, we review anorexia GWAS and enumerate the prospects and challenges of a genomics-driven approach towards personalized intervention in eating disorders.

Keywords: Eating disorders, genetics, GWAS, heterogeneity, anorexia nervosa, polygenic risk score, heritability, pathways.

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Article Details

VOLUME: 16
ISSUE: 8
Year: 2018
Page: [1102 - 1110]
Pages: 9
DOI: 10.2174/1570159X16666180222163450
Price: $58

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