Abstract
Heterogeneity, frequent diagnostic fluctuation across presentations, and global concerns with the absence of effective treatments all encourage science that moves the field toward individualized or precision medicine in eating disorders. We review recent advances in psychiatric genetics focusing on genome-wide association studies (GWAS) in eating disorders. Given that the only eating disorder to be the subject of GWAS to date is anorexia nervosa, we review anorexia GWAS and enumerate the prospects and challenges of a genomics-driven approach towards personalized intervention in eating disorders.
Keywords: Eating disorders, genetics, GWAS, heterogeneity, anorexia nervosa, polygenic risk score, heritability, pathways.
Current Neuropharmacology
Title:Updates on Genome-Wide Association Findings in Eating Disorders and Future Application to Precision Medicine
Volume: 16 Issue: 8
Author(s): Lauren Breithaupt, Christopher Hubel and Cynthia M. Bulik*
Affiliation:
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm,Sweden
Keywords: Eating disorders, genetics, GWAS, heterogeneity, anorexia nervosa, polygenic risk score, heritability, pathways.
Abstract: Heterogeneity, frequent diagnostic fluctuation across presentations, and global concerns with the absence of effective treatments all encourage science that moves the field toward individualized or precision medicine in eating disorders. We review recent advances in psychiatric genetics focusing on genome-wide association studies (GWAS) in eating disorders. Given that the only eating disorder to be the subject of GWAS to date is anorexia nervosa, we review anorexia GWAS and enumerate the prospects and challenges of a genomics-driven approach towards personalized intervention in eating disorders.
Export Options
About this article
Cite this article as:
Breithaupt Lauren , Hubel Christopher and Bulik M. Cynthia*, Updates on Genome-Wide Association Findings in Eating Disorders and Future Application to Precision Medicine, Current Neuropharmacology 2018; 16 (8) . https://dx.doi.org/10.2174/1570159X16666180222163450
DOI https://dx.doi.org/10.2174/1570159X16666180222163450 |
Print ISSN 1570-159X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6190 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Design and Development of Molecular Imaging Probes
Current Topics in Medicinal Chemistry Preparation, Pharmacokinetic and Application of Gold Nanoclusters (AuNCs) in Tumor Treatment
Current Medicinal Chemistry Inhibition of Monoamine Neurotransmitter Transporters and Central Nervous System Stimulation Induced by Synthetic Local Anesthetics and Cocaine: A Comparative Review-Update
Current Medicinal Chemistry - Central Nervous System Agents A Neuroinformatics Study Describing Molecular Interaction of Cisplatin with Acetylcholinesterase: A Plausible Cause for Anticancer Drug Induced Neurotoxicity
CNS & Neurological Disorders - Drug Targets A Review on the Recent Trends in Synthetic Strategies and Applications of Xanthene Dyes
Mini-Reviews in Organic Chemistry Kappa Opioids, Salvinorin A and Major Depressive Disorder
Current Neuropharmacology The Roles of the PDZ-containing Proteins Bridge-1 and PDZD2 in the Regulation of Insulin Production and Pancreatic Beta-Cell Mass
Current Protein & Peptide Science Subtype-Selective Dopamine Receptor Radioligands for PET Imaging: Current Status and Recent Developments
Current Medicinal Chemistry Dipeptidyl Peptidase IV Inhibitors: The Next Generation of New Promising Therapies for the Management of Type 2 Diabetes
Current Topics in Medicinal Chemistry Pyridoxal 5-Phosphate Enzymes as Targets for Therapeutic Agents
Current Medicinal Chemistry Pharmacophore Modeling and Docking Studies to Investigate Potential Leads for the Development of β -Secretase APP Cleavage Enzyme-1 (BACE-1) Inhibitors
Letters in Drug Design & Discovery The Discovery of VLA-4 Antagonists
Current Topics in Medicinal Chemistry Genetic and Environmental Factors in Complex Neurodevelopmental Disorders
Current Genomics Peripheral Biomarkers to Assess Suicide Risk
Current Psychiatry Reviews Kynurenine System and Multiple Sclerosis, Pathomechanism and Drug Targets with An Emphasis on Laquinimod
Current Drug Targets Improved Oral Absorption of Carbamazepine from 1-O-Alkylglycerol Stabilized o/w Nanoemulsions
Current Nanoscience Polyphenols: Well Beyond The Antioxidant Capacity: Polyphenol Supplementation and Exercise-Induced Oxidative Stress and Inflammation
Current Pharmaceutical Biotechnology Targeting TNF-Alpha to Elucidate and Ameliorate Neuroinflammation in Neurodegenerative Diseases
CNS & Neurological Disorders - Drug Targets Disease-Induced Neuroinflammation and Depression
CNS & Neurological Disorders - Drug Targets Astrocytes: Adhesion Molecules and Immunomodulation
Current Drug Targets