Heterogeneity, frequent diagnostic fluctuation across presentations, and global concerns
with the absence of effective treatments all encourage science that moves the field toward individualized
or precision medicine in eating disorders. We review recent advances in psychiatric genetics
focusing on genome-wide association studies (GWAS) in eating disorders. Given that the only eating
disorder to be the subject of GWAS to date is anorexia nervosa, we review anorexia GWAS and
enumerate the prospects and challenges of a genomics-driven approach towards personalized intervention
in eating disorders.
Keywords: Eating disorders, genetics, GWAS, heterogeneity, anorexia nervosa, polygenic risk score, heritability, pathways.
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