Bis-coumarins have caused great interests in the recent years. These compounds exhibit
diverse biological activities which are ascribed to their ability to exert noncovalent interactions with
the various active sites in organisms. Some of them such as dicoumarolum and dicoumarol were approved
for therapeutic purposes in clinical practice. Encouraged by the above facts, numerous biscoumarin
derivatives have been synthesized and screened for their biological activities, and many of
them showed promising potency. This review is focused on the biological potential of bis-coumarin
derivatives with particular mention of those exhibiting antibacterial, anticoagulant, antiinflammatory,
antiviral, anti-parasite and antitumor activities, and their structure-activity relationships
are also discussed.
Keywords: Bis-coumarin, anti-bacterial, antitumor, antiviral, hybrid compounds, structure-activity relationships.
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