Updates on GMSCs Treatment for Autoimmune Diseases

Author(s): Feng Huang, Zhong Ming Liu, Song Guo Zheng*.

Journal Name: Current Stem Cell Research & Therapy

Volume 13 , Issue 5 , 2018

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Abstract:

Background: Autoimmune disease is a refractory disease. Accumulating Evidence has revealed that the manipulation of mesenchymal stem cells may have the potential to control or even treat autoimmune diseases. Human gingiva-derived mesenchymal stem cells (GMSCs) are emerging as a new line of mesenchymal stem cells that have displayed some potential advantages in controlling and treating autoimmune diseases.

Objective: In this review, we briefly update the current understanding on the biology of GMSCs and their effects on preventing and treating autoimmune diseases.

Conclusion: The availability of gingival mesenchymal stem cells (GMSCs), together with their potent capacity of multi-directional differentiation and inflammatory modulation, making GMSCs an ideal subtype of MSCs in treating autoimmune disease. Our and other studies have launched the earliest appraisal on GMSCs and carried out a lot of biological researches. The clinical trial of GMSCs on patients with autoimmune diseases will further approve their therapeutic effects, as well as its cellular and molecular mechanisms.

Keywords: Autoimmune diseases, mesenchymal stem cells, human gingiva-derived mesenchymal stem cells, bone marrowderived mesenchymal stem cells, cell therapy.

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Article Details

VOLUME: 13
ISSUE: 5
Year: 2018
Page: [345 - 349]
Pages: 5
DOI: 10.2174/1574888X13666180220141114
Price: $58

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