Abstract
The WHO has estimated that one-fourth of the world’s population harbor a latent infection by MTB, and around 100-200 million individuals eventually develop an active TB. To make matters worse, drug-resistant MTB as well as the co-infection between MTB and HIV has further aggravated the mortality and spread of this disease. The quinolones have contributed an increasingly important chapter to the evolution of antimicrobials, and some of them were recommended as the second-line agents for the treatment of TB by WHO. Numerous 2-quinolone-based derivatives have been synthesized for searching new anti-TB agents, and some of them showed promising potency. This review aims to outline the recent advances made towards the discovery of 2-quinolone-based derivatives as potential anti-TB agents, and their structure-activity relationships are also discussed.
Keywords: Quinolone, hybrids, anti-mycobacterial, anti-tubercular, structure-activity relationship, co-infection.
Anti-Infective Agents
Title:Recent Advances of 2-Quinolone-Based Derivatives as Anti-Tubercular Agents
Volume: 16 Issue: 1
Author(s): Xiaocheng Liu, Jialun Deng, Zhi Xu*Zao-Sheng Lv
Affiliation:
- Key Laboratory of Hubei Province for Coal Conversion and New Carbon Materials, Wuhan University of Science and Technology, Hubei,China
Keywords: Quinolone, hybrids, anti-mycobacterial, anti-tubercular, structure-activity relationship, co-infection.
Abstract: The WHO has estimated that one-fourth of the world’s population harbor a latent infection by MTB, and around 100-200 million individuals eventually develop an active TB. To make matters worse, drug-resistant MTB as well as the co-infection between MTB and HIV has further aggravated the mortality and spread of this disease. The quinolones have contributed an increasingly important chapter to the evolution of antimicrobials, and some of them were recommended as the second-line agents for the treatment of TB by WHO. Numerous 2-quinolone-based derivatives have been synthesized for searching new anti-TB agents, and some of them showed promising potency. This review aims to outline the recent advances made towards the discovery of 2-quinolone-based derivatives as potential anti-TB agents, and their structure-activity relationships are also discussed.
Export Options
About this article
Cite this article as:
Liu Xiaocheng , Deng Jialun , Xu Zhi *, Lv Zao-Sheng, Recent Advances of 2-Quinolone-Based Derivatives as Anti-Tubercular Agents, Anti-Infective Agents 2018; 16 (1) . https://dx.doi.org/10.2174/2211352516666180215151216
DOI https://dx.doi.org/10.2174/2211352516666180215151216 |
Print ISSN 2211-3525 |
Publisher Name Bentham Science Publisher |
Online ISSN 2211-3533 |
Call for Papers in Thematic Issues
An Overview of Drugs for Multiple Targets and Variants of SARS-CoV-2 Through Artificial Intelligence, Machine Learning, Deep Learning, and Experimental Analysis
The emergence and rapid evolution of SARS-CoV-2 variants have posed significant challenges in the ongoing fight against the COVID-19 pandemic. The development of effective treatments for multiple viral targets and variants demands innovative approaches, including artificial intelligence (AI), machine learning (ML), and deep learning (DL) techniques. This special issue aims ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Is Renalase a Novel Player in Catecholaminergic Signaling? The Mystery of the Catalytic Activity of an Intriguing New Flavoenzyme
Current Pharmaceutical Design Recent Patents on Proteases and Kinases as Anti-Infective Agents: A Review
Recent Patents on Anti-Infective Drug Discovery Computational Drug Repositioning by Target Hopping: A Use Case in Chagas Disease
Current Pharmaceutical Design Chitosan Derivatives with Antimicrobial, Antitumour and Antioxidant Activities - a Review
Current Pharmaceutical Design Synthesis and Antibacterial Activity of Some Novel 1-(4-Oxo-3-(3- methoxyphenyl)-3H-quinazolin-2-yl)-4-(substituted) thiosemicarbazides
Anti-Infective Agents <I>In silico</I> Studies, Synthesis and Antitubercular Activity of Some Novel Quinoline - Azitidinone Derivatives
Current Computer-Aided Drug Design Mechanisms of Neutrophil-mediated Disease: Innovative Therapeutic Interventions
Current Pharmaceutical Design The Possible Potency of Ocimum basilicum New Constituent on Glucosestimulated Insulin Secretion In Vitro and β-cell Function In Vivo
Letters in Drug Design & Discovery MDR/XDRTB: What are the New Treatment Options?
Current Respiratory Medicine Reviews Understanding the Interaction Between Human Serum Albumin and Anti-Bacterial/ Anti-Cancer Compounds
Current Pharmaceutical Design The Effect of Chemotherapy/Radiotherapy on Cancerous Pattern Recognition by NK Cells
Current Medicinal Chemistry subject Index To Volume 3
Current Drug Targets Biologic Therapy in Inflammatory and Immunomediated Skin Diseases: Safety Profile
Current Drug Safety The Genus Glycosmis [Rutaceae]: A Comprehensive Review on its Phytochemical and Pharmacological Perspectives
The Natural Products Journal Antioxidant and Antimicrobial Activities of Cinnamic Acid Derivatives
Mini-Reviews in Medicinal Chemistry <i>Enoyl-Acyl Carrier Protein Reductase (INHA)</i>: A Remarkable Target to Exterminate Tuberculosis
Anti-Infective Agents Applications of Barbier Type Reactions in Carbohydrate Chemistry
Current Organic Synthesis Vitamin D and Metabolic Syndrome: Is There a Link?
Current Pharmaceutical Design Editorial (Thematic Issue: Nanotechnology for Drug Delivery Applications)
Current Drug Delivery Heterocyclic N-oxides - A Promising Class of Agents against Tuberculosis, Malaria and Neglected Tropical Diseases
Current Pharmaceutical Design