Biomedical Potentialities of Taraxacum officinale-based Nanoparticles Biosynthesized Using Methanolic Leaf Extract

Author(s): Tahir Rasheed, Muhammad Bilal*, Chuanlong Li, Hafiz M.N. Iqbal*.

Journal Name: Current Pharmaceutical Biotechnology

Volume 18 , Issue 14 , 2017

Submit Manuscript
Submit Proposal

Graphical Abstract:


Abstract:

Background: In the present study, the potential of methanolic leaf extract of Taraxacum officinale plant as a function of bio-inspired green synthesis for the fabrication of silver nanoparticles (AgNPs) has been explored.

Methods: The bio-reduction of aqueous silver nitrate (AgNO3) solution was confirmed by visually detecting the color change from pale yellow to blackish-brown. Maximum absorbance was observed at 420 nm due to the presence of characteristic surface Plasmon resonance of nano silver by UV-visible spectroscopy. The role of various functional groups in the bio-reduction of silver and chemical transformation was verified by Fourier transform infrared spectroscopy (FTIR). Scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDX) predict the shape (rocky, flack type, ellipsoidal, etc.), size (68 nm) and elemental composition (Ag as a major constituent) of the biosynthesized AgNPs, respectively.

Results: Transmission electron microscopy (TEM) analysis further corroborated the morphology of the AgNPs. Color mapping and atomic force microscopy (AFM) confirmed the nano-sized topography. The dynamic light scattering (DLS) showed the charge, stability, and size of the AgNPs. The generated AgNPs presented potential antibacterial activities against Gram-positive and Gram-negative bacterial strains including Staphylococcus aureus, Escherichia coli, and Haemophilus influenzae. The biosynthesized AgNPs also showed antiproliferative activity against MCF-7 breast cancer cell line in a dosedependent manner.

Conclusion: In conclusion, results clearly indicate that biosynthesized AgNPs could be used as effective nano drug for treating infectious diseases caused by multidrug resistant bacterial strains in the near future.

Keywords: Antibacterial, anti-biofilm, characterization, MCF-7 cell line, nanoparticles, Taraxacum officinale.

Rights & PermissionsPrintExport Cite as


Article Details

VOLUME: 18
ISSUE: 14
Year: 2017
Page: [1116 - 1123]
Pages: 8
DOI: 10.2174/1389201019666180214145421
Price: $58

Article Metrics

PDF: 14
HTML: 5
EPUB: 2
PRC: 1