GnRH antagonists have several clinical applications in prostate cancer, regulation of ovulation
induction in females, breast cancer, male contraception and others. Antagonists differ from natural
GnRH decapeptide in having five or more amino acid substitutions, whereas most of the antagonists are
available as subcutaneous (SC) formula for injection some are formulated as a depot formulation for
sustained release (e.g., Cetrorelix, Degarelix). Systemic delivery of cetrorelix acetate by intratracheal
route can be achieved using dry powder for inhalation of the adhesive mixture when the powder deposition
reaches stage four. The oral route for systemic delivery of peptide without its degradation can be
achieved using gastrointestinal permeation enhancement technology GIPET® provided by acyline.
Keywords: Cetrorelix, extrusion, GnHR antagonist, microparticles, peptide, subcutaneous, testesteron.
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