Background: Tumor cells may be expressed as a result of oxidative stress. The extent of
oxidative stress correlates with the aggressive and metastatic potency of cancer.
Objective: One simple way to control prostate cancer is through chemoprevention which refers to the
administration of natural or synthetic agents to block, reverse, or delay the process of carcinogenesis.
The most chemopreventive agents are antioxidants in nature.
Methods: In this review, we summarized the effects of dietary antioxidants with a focus on their molecular
mechanisms and possible roles in the treatment of prostate cancer cells. We also reported the
recent outcomes of laboratory and/or clinical trials of antioxidants in prostate cancer patients.
Results: Numerous pre-clinical studies showed that antioxidants protect DNA against being damaged by
Reactive Oxygen Species (ROS), thereby genetic mutations causing cancer are likely to be prevented.
However, the clinical trial results showed that antioxidants have yielded mixed outcomes or benefitted
only a subgroup of the population.
Conclusion: A greater understanding of the molecular events associated with antioxidants will enhance
the development of treatment and could result in better strategies for the chemoprevention of prostate
cancer. Recent patents also suggest that anti-oxidant compounds can be effective for the prevention and
the treatment of prostate cancer.