Background and Objective: There is great interest, supported by clinical experience, in the
relationship between Eating Disorders (EDs) and psychiatric symptoms and diseases. The psychopathology
of EDs is also referred to many risk and protective factors, and there is some evidence in the
literature, also about genetic and neurobiological factors involved. The aim of this review is to examine
and synthesize the recent scientific literature on this topic, in particular the complex relationship between
Anorexia Nervosa and Neuropsychiatric Disorders.
Methods: We analyzed the best of published literature on the topic, identifying keywords and MeSH
terms in Pubmed and then searching them. The last search was performed on November 2017.
Results: Psychiatric comorbidities are very common in anorexia nervosa. Mood disorders, major depressive
disorders, anxiety disorders, obsessive-compulsive disorders, developmental disorders among
autistic spectrum and attention-deficit hyperactivity disorder and even some personality disorders,
substance abuse and borderline traits have been reported, and some observations suggest a positive
genetic correlation between anorexia nervosa and schizophrenia.
Conclusion: The great amount of scientific articles dealing with the relationship between EDs and
psychopathology confirms the complexity of these problems and the difficulties in diagnosis and
treatment. An accurate diagnosis and assessment of clinical risk about psychological, psychiatric, nutritional
and somatic aspects are therefore essential for an appropriate therapeutic management of patients
affected by anorexia nervosa.