A very simple and efficient procedure for the preparation of primary amides is described
from carboxylic acids using Mukaiyama reagent/KNCO in aqueous acetonitrile. Availability of the
reagents, simplicity, and easy workup of the reaction crude make this method attractive for organic
Keywords: 2-Chloro-1-methylpyridinium iodide, acyl isocyanate, amide, carboxylic acid, mukaiyama reagent.
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