Direct and Facile Synthesis of Primary Amides from Carboxylic Acids via Acyl Isocyanate Intermediates Using Mukaiyama Reagent

Author(s): Roya Azadi* , Zahra Motamedpoor .

Journal Name: Letters in Organic Chemistry

Volume 15 , Issue 9 , 2018

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Abstract:

A very simple and efficient procedure for the preparation of primary amides is described from carboxylic acids using Mukaiyama reagent/KNCO in aqueous acetonitrile. Availability of the reagents, simplicity, and easy workup of the reaction crude make this method attractive for organic chemists.

Keywords: 2-Chloro-1-methylpyridinium iodide, acyl isocyanate, amide, carboxylic acid, mukaiyama reagent.

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Article Details

VOLUME: 15
ISSUE: 9
Year: 2018
Page: [801 - 804]
Pages: 4
DOI: 10.2174/1570178615666180212152643
Price: $58

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