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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Research Article

Direct and Facile Synthesis of Primary Amides from Carboxylic Acids via Acyl Isocyanate Intermediates Using Mukaiyama Reagent

Author(s): Roya Azadi* and Zahra Motamedpoor

Volume 15, Issue 9, 2018

Page: [801 - 804] Pages: 4

DOI: 10.2174/1570178615666180212152643

Price: $65

Abstract

A very simple and efficient procedure for the preparation of primary amides is described from carboxylic acids using Mukaiyama reagent/KNCO in aqueous acetonitrile. Availability of the reagents, simplicity, and easy workup of the reaction crude make this method attractive for organic chemists.

Keywords: 2-Chloro-1-methylpyridinium iodide, acyl isocyanate, amide, carboxylic acid, mukaiyama reagent.

Graphical Abstract

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