Title:Preliminary Human Radiation Dose Estimates of PET Renal Agents, Para-18F-Fluorohippuric Acid and Ortho-124I-Iodohippuric Acid from Rat Biodistribution Data
VOLUME: 11 ISSUE: 1
Author(s):Mohsen Cheki*, Maryam Papie, Luigi Mansi, Sean Kitson and Hariprasad Gali
Affiliation:Department of Radiologic Technology, Faculty of Paramedicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Department of Nuclear Engineering, Faculty of Mechanical Engineering, Shiraz University, Shiraz, Nuclear Medicine, Second University of Naples, Napoli, Department of Biocatalysis and Isotope Chemistry, Almac, 20 Seagoe Industrial Estate, Craigavon, BT63 5QD, Department of Pharmaceutical Sciences, College of Pharmacy, the University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Keywords:18F-PFH, 124I-OIH, PET, para-18F-fluorohippurate, ortho-124I-iodohippurate, renal agent, tubular secretion, renography,
dosimetry.
Abstract:Background: Para-18F-fluorohippuric acid (18F-PFH) and ortho-124I-iodohippuric acid (124IOIH)
were recently identified as potential radiotracers suitable for conducting renography using positron
emission tomography (PET). The aim of this work was to estimate preliminary human-equivalent internal
radiation dose of 18F-PFH and 124I-OIH using the biodistribution data reported in healthy rats. The
results were compared with the absorbed dose data of technetium-99m-mercaptoacetyltriglycine (99mTc-
MAG3) as documented in the International Commission on Radiological Protection (ICRP) publication
80.
Methods: The medical internal radiation dose (MIRD) formula was applied to extrapolate data from rats
to human and to project the absorbed radiation dose for various organs in humans. S factor was calculated
by Monte-Carlo N-particle (MCNP) simulation.
Results: Our dose prediction shows that an injection of 18F-PFH or 124I-OIH in humans would result in
an estimated effective absorbed dose of 0.09 or 0.17 µSv/MBq respectively for whole body, which is
about 135 or 73 times respectively lower than that obtained with an injection of 99mTc-MAG3. All organs
except kidneys would receive an estimated effective absorbed dose of <0.1 µSv/MBq for 18F-PFH
or 124I-OIH. Kidneys would receive a dose of 0.83 or 0.77 µSv/MBq respectively for 18F-PFH or 124I-OIH.
Conclusions: Our results indicate that 18F-PFH and 124I-OIH would deliver much safer levels and lower
radiation doses to the patients compared to 99mTc-MAG3 and warrants a clinical trial to estimate the
radiation doses more accurately.
