Title:Analytical Approaches to the Characterization of Solid Drug Delivery Systems with Porous Adsorbent Carriers
VOLUME: 25 ISSUE: 33
Author(s):Marko Krstić and Slavica Ražić*
Affiliation:Department of Pharmaceutical Technology and Cosmetology, University of Belgrade - Faculty of Pharmacy, Vojvode Stepe 450, P.O. Box 146, 11221 Belgrade, Department of Analytical Chemistry, University of Belgrade - Faculty of Pharmacy, Vojvode Stepe 450, P.O. Box 146, 11221 Belgrade
Keywords:Thermal analysis, TA, Infrared Spectroscopy, IR, Fourier Transform Infrared Spectroscopy, FTIR, Raman
spectroscopy, Powder X-Ray Diffraction, PXRD, Scanning Electron Microscopy (SEM) and drug dissolution.
Abstract:A large variety of analytical techniques are available to meet the needs of characterization
of solid samples. But, when solid drug delivery systems are concerned we are faced
with demanding methodologies which have to compile capabilities of analytical techniques in
regard to large diversity of structures and surface functionality of analyzed adsorbent carriers.
In this review, the most commonly used analytical techniques are presented with their basic
principles, advantages and disadvantages in applications of interest. Adsorbent carriers are
widely used today as ingredients in the formulation of pharmaceutical forms, for increasing
the dissolution rate of the drug and hence the bioavailability. They are also used in the formulation
of substances with modified or target drug release into a specific tissue. Methods of
thermal analysis (Thermogravimetry - TGA, Differential Scanning Calorimetry - DSC and
Thermal microscopy - TM), spectroscopic methods (Infrared Spectroscopy - IR, especially
Fourier Transform Infrared Spectroscopy - FTIR and Raman spectroscopy), crystallographic
methods (Powder X-Ray Diffraction - PXRD) and finally Scanning Electron Microscopy
(SEM) are the most powerful in the characterization of modern therapeutic systems with porous
adsorbents. The problem-solving power of each particular analytical method is often enhanced
by using simultaneous methods rather than a single technique.
