Background: The interest for polymeric nanogels is entirely justified taken into consideration
their diversity brought by the composition and their multiple applications, especially in the biomedical
field. Nanogels can be defined as three-dimensional networks with interconnected pores and
diameters below 100 nm. These materials exhibit distinct properties like swellability which can be
useful for entrapping and further release of bioactive substances. Nanogels combine the characteristics
of hydrogels (swelling capacity and retention of high amount of water, as well as tunable physicochemical
properties) with those of nanoparticles (large surface area which facilitates adsorption and
the possibility of being passed through the systemic circulation).
Objective: This review highlights the latest inventions in the field of nanogels synthesis. Thus, the recent
methods of preparation will be described as well as their use as nano-assemblies/nano-delivery
systems in the biomedical field.
Conclusions: There is an increasing interest in the study of nanogels due to their facile tailoring characteristics
and the ability to encapsulate bioactive substances. In spite of that, there are a lot of issues
that are necessary to assess the effectiveness of these materials regarding metabolism, biodistribution,
toxicity, immunogenicity and pharmacokinetics.