Background: Diabetic nephropathy is a crucial microvascular complication of diabetes
mellitus that is associated with elevated cardiovascular risk. SGLT-2 inhibitors are a new class of
hypoglycemic drugs that positively affect several risk factors of cardiorenal damage.
Objectives: The study aimed to review and critically discuss available data on the association of
SGLT-2 inhibitors treatment with kidney function, progress of diabetic kidney disease, and renal
related outcomes, as well to unveil potential mechanisms of action that mediate such effects.
Method: We conducted a comprehensive search of the literature on the renal related effects of
SGLT-2 inhibitors, to compose a narrative mini-review.
Results: The administration of SGLT-2 inhibitors was observed to exert beneficial effects on a wide
cluster of risk factors of chronic kidney disease, such as hyperglycemia, blood pressure, serum uric
acid, and body weight. Data from the first two large, randomized, clinical trials of SGLT-2 inhibitors
conducted to address the renal related outcomes of SGLT-2 inhibitors suggest substantial benefits
on estimated glomerular filtration rate decline and albuminuria.
Conclusion: The initial data suggest clinically meaningful benefits of the SGLT-2 inhibitors in
diabetic patients in relevance with chronic kidney disease. Future, well-designed randomised clinical
trials need to be further investigated such as nephroprotective outcomes, that if confirmed, could
lead to new perspectives in the management of diabetic nephropathy.