K+ Channels of Müller Glial Cells in Retinal Disorders

Author(s): Feng Gao, Lin-Jie Xu, Yuan Zhao, Xing-Huai Sun*, Zhongfeng Wang*.

Journal Name: CNS & Neurological Disorders - Drug Targets

Volume 17 , Issue 4 , 2018

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Abstract:

Background & Objective: Müller cell is the major type of glial cell in the vertebrate retina. Müller cells express various types of K+ channels, such as inwardly rectifying K+ (Kir) channels, big conductance Ca2+-activated K+ (BKCa) channels, delayed rectifier K+ channels (KDR), and transient A-type K+ channels. These K+ channels play important roles in maintaining physiological functions of Müller cells. Under some retinal pathological conditions, the changed expression and functions of K+ channels may contribute to retinal pathogenesis.

Conclusion: In this article, we reviewed the physiological properties of K+ channels in retinal Müller cells and the functional changes of these channels in retinal disorders.

Keywords: A-type K+ channels, BKCa channels, KDR, Kir channels, Müller cells, retinal disorders.

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Article Details

VOLUME: 17
ISSUE: 4
Year: 2018
Page: [255 - 260]
Pages: 6
DOI: 10.2174/1871527317666180202114233
Price: $58

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