Background & Objective: Müller cell is the major type of glial cell in the vertebrate retina.
Müller cells express various types of K+ channels, such as inwardly rectifying K+ (Kir) channels, big
conductance Ca2+-activated K+ (BKCa) channels, delayed rectifier K+ channels (KDR), and transient
A-type K+ channels. These K+ channels play important roles in maintaining physiological functions of
Müller cells. Under some retinal pathological conditions, the changed expression and functions of K+
channels may contribute to retinal pathogenesis.
Conclusion: In this article, we reviewed the physiological properties of K+ channels in retinal Müller
cells and the functional changes of these channels in retinal disorders.
Keywords: A-type K+ channels, BKCa channels, KDR, Kir channels, Müller cells, retinal disorders.
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