The aim of this literature review is to compile data of heterocyclic antigiardial agents. The
importance is to analyze the structural requirements for improved antigiardial activity, to overcome
resistance and enhance the bioavailability of the compounds under study. Though, nitroimidazoles/
imidazoles and benzimidazoles are major classes, other heterocyclic scaffolds viz.
oxoindolinylidene, dioxodihydroisobenzofuran-5-carboxamide, fluoroquinolone, thieno[2,3-b]pyridine-
5-carbonitrile, α-amino-phosphonate analogs of polyoxins, nitazoxanide benzologue, thiazole and triazolyl-
quinolone chalcone also possess activity against Giardia species. Heterocyclic phytoconstituents
are also included to have a deep idea of antigiardial activity of herbs possessing heterocyclic constituents.
Keywords: Antigiardial, heterocyclic constituents, nitroimidazole, benzimidazole, phytoconstituents, giardiasis.
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