Anticancer Activity Study of Chromone and Coumarin Hybrids using Electrical Impedance Spectroscopy

Author(s): Mustapha M. Bouhenna , Nabil Mameri* , Mónica V. Pérez , Oualid Talhi , Khaldoun Bachari , Artur M.S. Silva , Walter Luyten .

Journal Name: Anti-Cancer Agents in Medicinal Chemistry

Volume 18 , Issue 6 , 2018

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Abstract:

Aims: Oncology treatments aim at selective toxicity for tumor (compared to normal) cells, and chromone- coumarin hybrids have shown such activity.

Methods: In this study, we test a novel series of synthetic chromone and coumarin derivatives (1–9) for cytotoxic activity against a panel of tumor cell lines (MCF-7, A549, HepG2, HTC-116, B16 and Caco-2) opposed to non-tumor cells (HEK-293t). Electrical impedance spectroscopy was used to monitor cell viability in real time.

Results: Compound 8 showed the most potent activity, and it significantly diminished cancer cell proliferation and viability in different cell lines. It induced apoptosis in a dose-dependent manner, as shown by Western blot and flow cytometry.

Conclusion: Electrical impedance spectroscopy appears to be a convenient tool for in vitro cytotoxicity analysis, which could be useful for identifying drug effects and side effects during early phases of drug discovery and development.

Keywords: Coumarin, chromone, impedance, cell sine, anticancer, cytotoxicity.

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Article Details

VOLUME: 18
ISSUE: 6
Year: 2018
Page: [854 - 864]
Pages: 11
DOI: 10.2174/1871520618666180130102259
Price: $58

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