Cross-regulatory Circuit Between AHR and Microbiota

Author(s): Jian Ji, Hao Qu*.

Journal Name: Current Drug Metabolism

Volume 20 , Issue 1 , 2019


Graphical Abstract:


Abstract:

Background: The gut microbes have a close symbiotic relationship with their host. Interactions between host and the microbiota affect the nutritional, immunological, and physiological status of the host. The Aryl Hydrocarbon Receptor (AHR) is a ligand activated transcription factor that mediates the toxicity of xenobiotics. Recently, the relationship between the gut microbiota and AHR has attracted the attention of many researchers.

Methods: We undertook a structured search of bibliographic databases for peer-reviewed research literature.

Results: We found and reviewed 49 peer-reviewed papers dealing with the major aspects related to the crosstalk between AHR and microbiota. The AHR influences the intestinal microbiota population and mediates host-microbe homeostasis. Interestingly, the gut microbiota also produces ligands of AHR from bacterial metabolism and thereby activates the AHR signaling pathway.

Concusion: This review presents current knowledge of the cross-regulatory circuit between the AHR and intestinal microbiota. The findings of this review confirm the importance of AHR-microbiota interactions in health and disease.

Keywords: Aryl hydrocarbon receptor (AHR), ligand, xenobiotics, microbiota, cross-regulatory, homeostasis.

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Article Details

VOLUME: 20
ISSUE: 1
Year: 2019
Page: [4 - 8]
Pages: 5
DOI: 10.2174/1389200219666180129151150
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