Background: The gut microbes have a close symbiotic relationship with their host. Interactions between
host and the microbiota affect the nutritional, immunological, and physiological status of the host. The Aryl Hydrocarbon
Receptor (AHR) is a ligand activated transcription factor that mediates the toxicity of xenobiotics. Recently,
the relationship between the gut microbiota and AHR has attracted the attention of many researchers.
Methods: We undertook a structured search of bibliographic databases for peer-reviewed research literature.
Results: We found and reviewed 49 peer-reviewed papers dealing with the major aspects related to the crosstalk
between AHR and microbiota. The AHR influences the intestinal microbiota population and mediates host-microbe
homeostasis. Interestingly, the gut microbiota also produces ligands of AHR from bacterial metabolism and thereby
activates the AHR signaling pathway.
Concusion: This review presents current knowledge of the cross-regulatory circuit between the AHR and intestinal
microbiota. The findings of this review confirm the importance of AHR-microbiota interactions in health and disease.