Background: Constant exposure to various stressors, such as immune pressure, rapidly increasing population,
deleterious changes in the ecosystem, climate change, infection with emerging and re-emerging pathogens, and
fast-paced lifestyle, is a critical factor in the globally increasing incidences of immunocompromising health conditions,
as well as stress. Synthetic chemotherapeutic agents, which are widely available in the commercial market,
may be highly efficacious, but most are immunosuppressive and exert many side effects.
Methods: Herein, we comprehensively reviewed current literature from various scientific databases such as Bentham
Science, PubMed, Scopus, Elsevier, Springer, etc. The inclusion/exclusion criteria based on literature with high importance
was adopted to analyze and compile salient information from the authentic bibliographic sources.
Results: Undoubtedly, the pivotal characteristics of immunostimulants and immunomodulators in the maintenance of
the health and productivity of humans, as well as animals, cannot be overlooked. Numerous herbs used in ethnoveterinary
medicine can be successfully employed as adjuvant rehabilitators to negate the deleterious effects of chemotherapeutics.
The sources of these medicinal remedies are part of long traditions in different regions of the world,
such as Indian Ayurveda and Traditional Chinese Medicine, which have been developed through empirical experience.
Traditional medicine employs a holistic approach to the prevention of disease, and traditional herbal medicines
are a source of many components with a high therapeutic value that are used in modern allopathic medicine. Globally,
many studies have been conducted on these herbs and have revealed unique active constituents that activate the
innate immune system through the stimulation of macrophages and lymphocytes, and modulation of the cytokine
profile, which leads to a state of alertness with a subsequent reduction in the incidence of infection. Immunomodulatory
constituents with herbal origins are termed as phytochemicals, including flavonoids, glycosides, polysaccharides,
terpenoids, essential oils, various bitters, and alkaloids; all these compounds exert vital, multidimensional
effects. Efforts have focused on screening plant preparations to identify adjuvant immune properties; furthermore,
several potent phytol adjuvants have been experimentally proven to downregulate inflammatory reactions in addition
to enhance specific adaptive responses to vaccines.
Conclusions: In summary, this review summarizes the current status and future prospects regarding the immunomodulatory
potential of various herbs and plants and their promising utility for designing and developing effective
drugs and medicines in safeguarding the health of humans, animals, and poultry.