Advances in the Development of Anticancer HSP-based Vaccines

Author(s): Alexey V. Baldin, Andrey A. Zamyatnin Jr, Alexandr V. Bazhin, Wan-Hai Xu, Lyudmila V. Savvateeva*.

Journal Name: Current Medicinal Chemistry

Volume 26 , Issue 3 , 2019

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Abstract:

Current advances in cancer treatment are based on the recent discoveries of molecular mechanisms of tumour maintenance. It was shown that heat shock proteins (HSPs) play a crucial role in the development of immune response against tumours. Thus, HSPs represent multifunctional agents not only with chaperone functions, but also possessing immunomodulatory properties. These properties are exploited for the development of HSP-based anticancer vaccines aimed to induce cytotoxic responses against tumours. To date, a number of strategies have been suggested to facilitate HSP-based vaccine production and to increase its effectiveness. The present review focuses on the current trend for the development of HSPbased vaccines aimed at inducing strong immunological tumour-specific responses against cancer cells of distinct etiology and localization.

Keywords: Heat shock proteins, chaperones, immune response, anticancer vaccine, tumor-associated antigens, tumor- specific antigens.

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VOLUME: 26
ISSUE: 3
Year: 2019
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DOI: 10.2174/0929867325666180129100015
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