Background: Various mediators and anti-inflammatory drugs were used since
from a long time but it is still a challenge for the medicinal chemists to treat or reduce the
symptoms of inflammatory diseases. Most of the clinically used anti-inflammatory drugs
such as NSAIDs, Coxibs and GCs are allied with considerable toxicity.
Objective: The search of novel anti-inflammatory agent is not an ending process. Although
the drug treatment has been improved steadily but yet, it is still there is a need to develop
more potent therapeutic agents.
Method: Reported literature survey has been studied to summarize the nitrogen containing
moieties which were utilized as potential therapeutic agents.
Results: A variety of N-heterocyclic analogs are known to exhibit a wide range of interesting
biological activities like antioxidant, anti-inflammatory, anticonvulsant, analgesic, antimicrobial,
anticancer, antiprotozoal, antioxidant, antiparasitic, antiplatelet, cardioprotective,
anthelmintic, antidiabetic, antitubercular, trypanocidal and anti-HIV. However, numerous
approaches were used to overcome the toxicity level such as co-administration with
suitable agent/substance which provides protection against toxicity as well to synthesise
new potent and safe anti-inflammatory drug.
Conclusion: The present review summarizes the synthetic methodology and therapeutic potential
of some N-heterocyclic analogs as potent anti-inflammatory agents.