Introduction: Pseudomonas aeruginosa is an opportunistic pathogen leading to severe,
acute and chronic infections in burn patients. In the process of wound healing, a significant delay in
the closure of excisional wound sites is due to the bacterial skin infection, so anti-infection is important
in wound healing.
Objective: Abuse of antibiotics leads to the development of multi drug resistance of P. aeruginosa
strains which requires a rapid intervention to find a solution focusing on new natural antibacterial
pathways. Punica granatum (pomegranate) has emerged as a medicinal plant with potential antimicrobial
activity. The present study was planned to evaluate this activity against P. aeruginosa collected
from burn wound cultures.
Methods: Aqueous extract of sweet pomegranate peels from Safita, a mountainous region west of Syria
was prepared. Minimum inhibitory concentration (MIC) and antivirulence efficacy were determined
for the -prepared extract.
Results: MIC was 1.4 mg/ml and bacterial gelatinase and lecithinase activities were reduced by
40.28±2.35% and 53.84±4.89%, respectively.
Conclusion: The extracts from pomegranate fruit peel possess strong antimicrobial and antivirulence
activities against P. aeruginosa. Therefore, this plant could be an important source of new antimicrobial