Background and Objective: Metabolomics is a powerful exploratory tool for discovering
new diagnostic molecules or biomarkers due to its ability to highlight several interactions between
different biochemical molecules and pathways in composition in health and disease thereby advancing
our understanding, to provide evidence based diagnosis and treatment of such a complex disease including
polycystic ovarian syndrome (PCOS). The aim of this study was to review available literature
on the use of metabolomic approach and to critically evaluate and draw a synthesis to highlight novel
biochemical markers for clinical application in PCOS.
Method: Studies that applied metabolomic approach to investigate PCOS and those meeting selection
criteria were searched and, critically evaluated.
Result: Here we highlighted the metabolic reactions and perturbation of some metabolic pathways
present in patients with polycystic ovarian syndrome and normal subjects that can allow better understanding
of the disorder and help developing a new generation diagnostic and treatment algorithm.
Conclusion: A number of disease-related metabolites have been discussed which have extraordinary
potential for a clinical utility as diagnostic and treatment monitoring biomarkers.