Background: Microalgae have been suggested as promising feedstocks of significant
biotechnological interest due to their enormous potential for the sustainable production of
industrially valuable compounds such as lipids/fatty acids, proteins, metabolites, pigments, and
biofuels. However, exploitation of algal biomass for commercial purposes is still in its infancy due
to the dearth of the knowledge regarding state-of-the-art sophisticated technologies.
Objectives: The main objective of the study was to review the explosions of innovative strategies
that biological sciences have witnessed over the past several years, enabling the scientific community
and research-based organizations to scrutinize entire classes of biomolecules from a cell type
or whole organism, collectively titled as 'Omics, including genomics, transcriptomics, proteomics
Methods: An effort has been made to analyze the relative advantages and drawbacks of these technologies
by reviewing and consulting the available literature.
Results: Nevertheless, these 'Omics strategies have played a key role in the better understanding of
the underlying mechanisms of specific gene products, regulatory constraints, metabolic pathways
and potential genes and protein targets which might be employed in tailoring microalgae for
enhanced productivity. In this critical review, an understanding of recent omics technologies, their
potential applications, and limitations for microalgae-based fuel and other commodity chemicals
are comprehensively discussed.
Conclusion: In the scenario of uncertain petro-based reserves, global warming and energy insecurity,
the exploration of metabolic potentialities of microalgae using “Omics” are believed to be a
green and environmentally-responsive approach that will further expand its industrial and environmental