Background: Pancreatic cancer is a difficult malignancy to manage with little
improvement in mortality rates over time. Local control remains a challenge. The objective
of this review is to discuss patient selection and technical considerations for the safe
utilization of stereotactic body radiotherapy (SBRT).
Methods: An online search was completed to review available data. The current literature
examining the use and delivery of SBRT for pancreatic cancer was reviewed and
summarized. Patient selection criteria, technical considerations, and the implementation
of SBRT are described.
Results: Studies thus far have shown promising outcomes for SBRT in terms of potential
for conversion from borderline or unresectable to resectable disease as well as the
feasibility of delivering SBRT safely.
Conclusion: SBRT represents an emerging treatment option for patients to improve local
control through delivery of ablative, high-dose radiation while reducing radiation
treatment time as compared to conventionally fractionated chemoradiation. Further studies
are needed to explore the full potential and toxicities of SBRT in pancreatic cancer.
The importance of technical considerations in this modality cannot be overstated.
Keywords: Surveillance, Epidemiology, and End Results Program (SEER), cancer, Celiac Axis (CA),
Superior Mesenteric Artery (SMA), Common Hepatic Artery (CHA), chemoradiation.
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