Synthesis and Biological Screening of Lupeol-benzylidine Derivatives

Author(s): Devendra S. Rao, Uma Devi Parimi*, Nageswara B. Rao, Karteek A. Rao.

Journal Name: The Natural Products Journal

Volume 8 , Issue 3 , 2018

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Abstract:

Background: Lupeol, a pentacyclic triterpenoid is found in the stem-bark of Walsura trifoliate. Derivatives of lupeol are associated with a broad range of biological activities.

Objective: To synthesis a series of Lupeol-benzylidine derivatives and evaluate their antimicrobial and antiproliferative acitivities.

Method: Lupeol was isolated from the bark of Walsura trifoliate. The ring A at C2 position of Lupeol was modified by claisens Schmidt condentation to produce Lupeol-benzylidine derivatives. Antimicrobial assay was performed by broth dilution technique.

Results: All the structures were confirmed by 1HNMR, 13CNMR and IR spectroscopic techniques. Compounds 3c and 3h exhibited the highest activity.

Conclusion: In conclusion, a series of different benzylidine derivatives from natural product Lupeol have been synthesized. All the tested compounds are found to be as antimicrobial and antiproliferative agents.

Keywords: Walsura trifoliata, Lupeol, benzylidine derivatives, pentacyclic triterpenoid, anti proliferative activities, claisens condensation.

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Article Details

VOLUME: 8
ISSUE: 3
Year: 2018
Page: [196 - 200]
Pages: 5
DOI: 10.2174/2210315508666180117154929
Price: $58

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