Background: Lupeol, a pentacyclic triterpenoid is found in the stem-bark of Walsura trifoliate.
Derivatives of lupeol are associated with a broad range of biological activities.
Objective: To synthesis a series of Lupeol-benzylidine derivatives and evaluate their antimicrobial
and antiproliferative acitivities.
Method: Lupeol was isolated from the bark of Walsura trifoliate. The ring A at C2 position of Lupeol
was modified by claisens Schmidt condentation to produce Lupeol-benzylidine derivatives.
Antimicrobial assay was performed by broth dilution technique.
Results: All the structures were confirmed by 1HNMR, 13CNMR and IR spectroscopic techniques.
Compounds 3c and 3h exhibited the highest activity.
Conclusion: In conclusion, a series of different benzylidine derivatives from natural product Lupeol
have been synthesized. All the tested compounds are found to be as antimicrobial and antiproliferative