The Role of Colchicine in the Treatment of Autoinflammatory Diseases

Author(s): Georgia Liantinioti , Antonios A. Argyris* , Athanase D. Protogerou , Panayiotis Vlachoyiannopoulos .

Journal Name: Current Pharmaceutical Design

Volume 24 , Issue 6 , 2018

Abstract:

Colchicine has been longstanding and widely used for the treatment of acute gout flares and prevention of gout relapses. Its use has been extended to a series of autoinflammatory diseases, such as familial Mediterranean fever and more recently to periodic fever with aphthous stomatitis, pharyngitis and adenitis, Behcet’s disease and idiopathic recurrent acute pericarditis. In this review, we summarize current indications of colchicine use, discuss its pharmacokinetics and mechanism of action and examine its use in the treatment of autoinflammatory diseases. Further understanding of the underlying mechanisms of the latter conditions as well as identification of the therapeutic efficacy and treatment target of colchicine may lead to more effective management of these diseases.

Keywords: Colchicine, autoinflammatory diseases, acute gout flares, Behcet's disease, pharyngitis, familial Mediterranean fever.

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Article Details

VOLUME: 24
ISSUE: 6
Year: 2018
Page: [690 - 694]
Pages: 5
DOI: 10.2174/1381612824666180116095658
Price: $58

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