Background: In the study of lipid vesicular carriers in permeation enhancement of drug
molecules across skin after the success story of liposomes, ethosomes are a recent addition. There are a
number of published reviews but still, there is a lack of reviews representing various aspects in a systematic
way with a detailed description of current research works. This review serves to fill this deficiency
along with special emphasize on its preparation methods and applications.
Methods: Information was collected from previously published literatures which were represented after
analysis in terms of various aspects such as principles, composition, preparation, mechanism of penetration,
modified forms, characterization, marketed preparations and its applications.
Result: This review is represented in an informative and easily understandable way. Basic principles
and background were covered in the introduction section. Composition section contains the basic components
of formulations along with the impact of various parameters on the characterization of the ethosome.
A detailed discussion of all the methods along with their own utility is elaborately provided.
Various aspects of characterization studies of ethosomes are also discussed. Therapeutic and cosmetic
applications of ethosomes are also outlined here.
Conclusion: In spite of having a excellent permeation-enhancing and targeted drug release profile,
ethosome suffers from limited commercialization. Various challenges regarding their commercialization
and product development are also discussed in this review with an objective of acting as a directional
route for the researchers.