A great number of new drug candidates identified from the discovery pipeline are poorly
water soluble, which is a drawback to bring such candidates into the pharmaceutical market. Formulating
these compounds as self-emulsifying/microemulsifying/ nanoemulsifying drug delivery systems
(SEDDS/SMEDDS/SNEDDS) within lipid based formulations is of growing interest. Some of the recent
studies have resulted in commercial products that provided improved bioavailability and dissolution
due to the better dispersion properties of SEDDS/SMEDDS/SNEDDS. An ongoing challenge that
the pharmaceutical industry is facing is identifying in vitro tests that are needed in order to predict the
behavior of dosage forms in the GI tract. The goal of the current review is to present the various levels
of in vitro-in vivo correlations (IVIVCs) and to provide tools on the utilization of the IVIVCs in product
development and optimization of SEDDS/SMEDDS/SNEDDS.
Keywords: Lipid based formulation, SEDDS/SMEDDS/SNEDDS, poorly water soluble drugs, dissolution, lipolysis, IVIVC.
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