Background: A common phenotype associated with heart failure is the development of
cardiac hypertrophy. Cardiac hypertrophy occurs in response to stress, such as hypertension, coronary
vascular disease, or myocardial infarction. The most critical pathophysiological conditions involved
may include dilated hypertrophy, fibrosis and contractile malfunction. The intricate pathophysiological
mechanisms of cardiac hypertrophy have been the core of several scientific studies,
which may help in opening a new avenue in preventive and curative procedures.
Objectives: To our knowledge from the literature, the development of cardiac remodeling and hypertrophy
is multifactorial. Thus, in this review, we will focus and summarize the potential role of
oxidative stress in cardiac hypertrophy development.
Conclusion: Oxidative stress is considered a major stimulant for the signal transduction in cardiac
cells pathological conditions, including inflammatory cytokines, and MAP kinase. The understanding
of the pathophysiological mechanisms which are involved in cardiac hypertrophy and remodeling
process is crucial for the development of new therapeutic plans, especially that the mortality
rates related to cardiac remodeling/dysfunction remain high.