An Overview of Discovery of Thiazole Containing Heterocycles as Potent GSK-3β Inhibitors

Author(s): Deepika Sharma*, Anjleena Malhotra, Ranju Bansal.

Journal Name: Current Drug Discovery Technologies

Volume 15 , Issue 3 , 2018

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Abstract:

Glycogen synthase kinase-3 (GSK-3) is a multifunctional serine/threonine (ser/thr) kinase that was originally identified as a regulator of glycogen metabolism and coupled with insulin signaling. Due to multifunctionality of this enzyme, it is found to play an important role in the onset and progression of various human diseases. Thiazole nucleus has received special attention by medicinal chemists because of its wide therapeutic potential. The objective of this review is to cover all the aspects of GSK-3β enzyme including its clinical implications, types of inhibitors with special reference to thiazole as GSK-3β inhibitor. Literature search was performed using Pubmed/Medline and Google Scholar to search for articles published in English language.

Keywords: Thiazole, GSK-3β, GSK-3β inhibitor, heterocycles, protein kinases, enzyme.

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Article Details

VOLUME: 15
ISSUE: 3
Year: 2018
Page: [229 - 235]
Pages: 7
DOI: 10.2174/1570163815666180104120857
Price: $58

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