Glycogen synthase kinase-3 (GSK-3) is a multifunctional serine/threonine
(ser/thr) kinase that was originally identified as a regulator of glycogen metabolism
and coupled with insulin signaling. Due to multifunctionality of this enzyme, it is
found to play an important role in the onset and progression of various human diseases.
Thiazole nucleus has received special attention by medicinal chemists because
of its wide therapeutic potential. The objective of this review is to cover all the aspects
of GSK-3β enzyme including its clinical implications, types of inhibitors with
special reference to thiazole as GSK-3β inhibitor. Literature search was performed
using Pubmed/Medline and Google Scholar to search for articles published in English
Keywords: Thiazole, GSK-3β, GSK-3β inhibitor, heterocycles, protein kinases, enzyme.
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