Background: Psoriasis is a chronic immune-mediated inflammatory skin disorder that is estimated
to affect 2-3% of the general population. The IL-23/IL-17 axis is currently considered to be
crucial in the pathogenesis of psoriasis.
Methods: Biologics licensed for psoriasis include the TNFα inhibitors (infliximab, adalimumab, etanercept),
the interleukin (IL)-12/23 monoclonal antibody (ustekinumab), and IL-17 inhibitor (secukinumab,
Results: In this section, we analyse the role of IL-12, IL-23, and IL-17 in psoriasis and evaluated the
efficacy and safety of biologic therapies targeting this cytokine.
Conclusion: Dosing regimens, administration modality, and pharmacodynamics profiles of currently
available anti-IL-12/IL-23 and IL-17 inhibitors are also examined.