Molecular Insights into Muscle Homeostasis, Atrophy and Wasting

Author(s): Bianca Maria Scicchitano* , Gabriella Dobrowolny , Gigliola Sica , Antonio Musaro* .

Journal Name: Current Genomics

Volume 19 , Issue 5 , 2018

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Abstract:

Muscle homeostasis is guaranteed by a delicate balance between synthesis and degradation of cell proteins and its alteration leads to muscle wasting and diseases.

In this review, we describe the major anabolic pathways that are involved in muscle growth and homeostasis and the proteolytic systems that are over-activated in muscle pathologies. Modulation of these pathways comprises an attractive target for drug intervention.

Keywords: Muscle homeostasis, Muscle atrophy, Degradation of cell proteins, Muscle wasting, Anabolic pathways, Muscle pathologies.

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Article Details

VOLUME: 19
ISSUE: 5
Year: 2018
Page: [356 - 369]
Pages: 14
DOI: 10.2174/1389202919666180101153911
Price: $58

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