Coumarin Derivatives as Anticancer Agents for Lung Cancer Therapy: A Review

Author(s): Manvendra Kumar, Ramit Singla, Jyoti Dandriyal, Vikas Jaitak*.

Journal Name: Anti-Cancer Agents in Medicinal Chemistry

Volume 18 , Issue 7 , 2018

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Abstract:

Background: The prevalence of lung cancer is 14% among the newly diagnosed cancer cases worldwide. Currently, the number of drugs that are in clinical practice is having a high prevalence of side effect and multidrug resistance. Researchers have made an attempt to expand a suitable anticancer drug that has no MDR and side effect.

Objective: Extensive exploration of Coumarin derivatives as a potent inhibitor of variety of proteins including EGFR, tyrosine kinase, ERK1/2, PI3K, HSP 90, Bax, STAT proteins, NF-κB and telomerase which have been associated with lung cancer.

Method: The recent literature was surveyed utilizing the online resources and databases including scifinder, pubchem, EMBL, scopus and google scholar.

Results: Upon analyzing the structure-activity relationship, it was found that N-aryl carboxamide, phenyl substitution at the C-3 position and 1,2,3- triazolyl, trihydroxystilbene, amino substitution at the C-4 position of the coumarin nucleus were the most effective in targeting lung cancer.

Conclusion: This review is a collaborative and extensive compilation of synthetic strategies, mechanism of action, and the structure-activity relationship thereof for the management of lung carcinoma.

Keywords: Lung cancer, MDR, coumarin, NSCLC, SCLC, multidrug resistance.

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Article Details

VOLUME: 18
ISSUE: 7
Year: 2018
Page: [964 - 984]
Pages: 21
DOI: 10.2174/1871520618666171229185926
Price: $58

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