Synthesis and Bioevaluation of Shikonin Derivatives

Author(s): Sufen Cao, Jiangang Zhang, Wenhu Duan*.

Journal Name: Letters in Drug Design & Discovery

Volume 15 , Issue 9 , 2018

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Abstract:

Background: Ester and amide derivatives of shikonin were synthesized to improve the chemical stability of shikonin.

Methods: All synthesized compounds were evaluated for their antiproliferative activity against A549 cell line by SRB assay, and five of them demonstrated comparable cytotoxicity to shikonin.

Results and Conclusion: The most potent compound, 22d, was more stable and potent than shikonin.

Keywords: Amidation, chemical stability, cytotoxicity, esterification, shikonin derivatives, synthesis, SRB assay, cell lines.

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Article Details

VOLUME: 15
ISSUE: 9
Year: 2018
Page: [945 - 950]
Pages: 6
DOI: 10.2174/1570180815666171229152139
Price: $58

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