Background: Ester and amide derivatives of shikonin were synthesized to improve the
chemical stability of shikonin.
Methods: All synthesized compounds were evaluated for their antiproliferative activity against
A549 cell line by SRB assay, and five of them demonstrated comparable cytotoxicity to shikonin.
Results and Conclusion: The most potent compound, 22d, was more stable and potent than
Keywords: Amidation, chemical stability, cytotoxicity, esterification, shikonin derivatives, synthesis, SRB assay, cell lines.
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