Current Status and Perspectives on Pharmacologic Therapy for Abdominal Aortic Aneurysm

Title:Current Status and Perspectives on Pharmacologic Therapy for Abdominal Aortic Aneurysm

Volume: 19 Issue: 11

Author(s): Koichi Yoshimura*, Noriyasu Morikage, Shizuka Nishino-Fujimoto, Akira Furutani, Bungo Shirasawa and Kimikazu Hamano

Affiliation:

• Department of Surgery and Clinical Science, Yamaguchi University Graduate School of Medicine, Ube, 755-8505,Japan

Keywords: Abdominal aortic aneurysm, pharmacologic therapy, medical management, progression, animal study, clinical study, practice guideline, future perspective.

Abstract: Background: Abdominal aortic aneurysm (AAA), a common disease involving the segmental expansion and rupture of the aorta, has a high mortality rate. Therapeutic options for AAA are currently limited to surgical repair to prevent catastrophic rupture. Non-surgical approaches, particularly pharmacotherapy, are lacking for the treatment of AAA.

Objective: We review both basic and clinical studies and discuss the current challenges to developing medical therapy that reduces AAA progression.

Results: Studies using animal models of AAA progression and human AAA explant cultures have identified several potential targets for preventing AAA growth. However, no clinical studies have convincingly confirmed the efficacy of any pharmacologic treatment against the growth of AAA. Thus, there is as yet no strong recommendation regarding pharmacotherapy to reduce the risk of AAA progression and rupture.

Conclusion: This review identifies concerns that need to be addressed for the field to progress and discusses the challenges that must be overcome in order to develop effective pharmacotherapy to reduce AAA progression in the future.

Cite this article as:

Yoshimura Koichi *, Morikage Noriyasu , Nishino-Fujimoto Shizuka , Furutani Akira , Shirasawa Bungo and Hamano Kimikazu , Current Status and Perspectives on Pharmacologic Therapy for Abdominal Aortic Aneurysm, Current Drug Targets 2018; 19 (11) . https://dx.doi.org/10.2174/1389450119666171227223331