Structure Activity Relationship of Venom Toxins Targeting Potassium Channels

Author(s): Sidra Batool* , Nighat Noureen , Mohammad Amjad Kamal .

Journal Name: Current Drug Metabolism

Volume 19 , Issue 8 , 2018


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Abstract:

Background: Peptide toxins are naturally occurring rich sources of highly specific bioactive compounds from venomous animals acting on various types of ion channels.

Objective: This study mainly highlights targeting of one of the largest families of ion channels i.e. potassium channels via venom toxins.

Method: Data for reported venom toxins from diverse species is gathered and analyzed at sequence and structural extent.

Results: The similarities and differences among toxins have been demonstrated along with structure activity relationship of potassium channels with these toxins.

Conclusion: This review highlights the importance of functionally important residues and structural scaffolds of venoms interacting with potassium channels.

Keywords: Venom toxins, potassium channels, structure scaffolds, pore blockers, kunitz type toxins, gating modifiers, disulphide bridges.

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Article Details

VOLUME: 19
ISSUE: 8
Year: 2018
Page: [714 - 720]
Pages: 7
DOI: 10.2174/1389200219666171227205009
Price: $58

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